Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus. Cutaneous vasculitic toxicities, including vasculitic ulcerations and gangrene, have occurred in patients with myeloproliferative disorders during therapy with hydroxyurea. Renal Insufficiency As renal excretion is pathway of elimination, consideration should be given to decreasing the dosage of Hydroxyurea in patients with renal impairment. OTHER USES: This section contains uses of this drug that are not listed in the approved professional buy cheap hydrea mar wajer trasferiment labeling for the drug but that may be prescribed by your health care professional. Times the maximum recommended human daily dose on mg m2 basis to rats caused growth retardation and impaired learning ability. Erythrocytic abnormalities: megaloblastic erythropoiesis, which is self-limiting, is often seen early in the course of Hydroxyurea therapy.